Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 6
Ligand
BDBM466677
Substrate
n/a
Meas. Tech.
High Throughput Screening Assay
IC50
635±n/a nM
Citation
 Bouyssou, T; Gottschling, D; Heine, N; Keenan, LL; Lowe, MD; Razavi, H; Sarko, CR; Surprenant, S; Takahashi, H; Turner, MR; Wu, X Inhibitors of TRPC6 US Patent  US10800757 Publication Date 10/13/2020 
Target
Name:
Short transient receptor potential channel 6
Synonyms:
TRP-6 | TRP6 | TRPC6 | TRPC6_HUMAN | Transient receptor protein 6
Type:
PROTEIN
Mol. Mass.:
106326.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107640
Residue:
931
Sequence:
MSQSPAFGPRRGSSPRGAAGAAARRNESQDYLLMDSELGEDGCPQAPLPCYGYYPCFRGSDNRLAHRRQTVLREKGRRLANRGPAYMFSDRSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILSHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCNDCNQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETLQSGDHGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWFAPCSKMGKIMRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNAKQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLFYLLLKLKKWISELFQGHKKGFQEDAEMNKINEEKKLGILGSHEDLSKLSLDKKQVGHNKQPSIRSSEDFHLNSFNNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRELGEKLSMEPNQEETNR
  
Inhibitor
Name:
BDBM466677
Synonyms:
4-Methoxy-5-[1-(4-methoxy-5-{[trans- 3-(trifluoromethyl)cyclobutyl]- methoxy}pyridine-2-carbonyl)- piperidin-4-yl]pyridin-2-amine | US10800757, Compound 92 | US10889568, Compound 92
Type:
Small organic molecule
Emp. Form.:
C24H29F3N4O4
Mol. Mass.:
494.5067
SMILES:
COc1cc(ncc1OC[C@H]1C[C@@H](C1)C(F)(F)F)C(=O)N1CCC(CC1)c1cnc(N)cc1OC |r,wU:10.10,wD:12.15,(-3.72,4.23,;-3.72,2.69,;-2.39,1.92,;-1.06,2.69,;.28,1.92,;.28,.38,;-1.06,-.38,;-2.39,.38,;-3.72,-.39,;-5.06,.38,;-6.39,-.39,;-6.79,-1.87,;-8.28,-1.47,;-7.88,.01,;-9.61,-2.24,;-10.95,-1.47,;-9.61,-3.78,;-10.95,-3.01,;1.61,2.69,;1.61,4.23,;2.94,1.93,;2.94,.38,;4.28,-.38,;5.61,.38,;5.61,1.93,;4.28,2.69,;6.94,-.38,;8.28,.38,;9.61,-.38,;9.61,-1.93,;10.95,-2.69,;8.28,-2.7,;6.94,-1.93,;5.61,-2.69,;5.61,-4.23,)|
Structure:
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