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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM466760
Substrate
n/a
Meas. Tech.
HPK1 Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Pan, J; Sokolsky, A; Styduhar, E; Yao, W Carboxamide compounds and uses thereof US Patent  US10800761 Publication Date 10/13/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM466760
Synonyms:
US10800761, Example 79 | US11731958, Example 79
Type:
Small organic molecule
Emp. Form.:
C24H25FN4O2
Mol. Mass.:
420.4793
SMILES:
COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccccc1[C@@H]1CC[C@H](N)CC1 |r,wU:24.26,27.30,(-6,8.25,;-4.67,7.48,;-3.33,8.25,;-3.33,9.79,;-2,10.56,;-.67,9.79,;-.67,8.25,;.67,7.48,;-2,7.48,;-2,5.94,;-3.33,5.17,;-3.33,3.63,;-2,2.86,;-.67,3.63,;-.67,5.17,;.67,2.86,;.67,1.32,;2,3.63,;3.33,2.86,;3.33,1.32,;4.67,.55,;6,1.32,;6,2.86,;4.67,3.63,;4.67,5.17,;6,5.94,;6,7.48,;4.67,8.25,;4.67,9.79,;3.33,7.48,;3.33,5.94,)|
Structure:
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