Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM276743
Substrate
n/a
Meas. Tech.
Human, Dog and Rat c-Fms Enzyme Assay
IC50
11.0±n/a nM
Citation
 Chen, JDonahue, MLim, HLin, RSalter, RWu, JGong, Y Substituted pyridine derivatives useful as C-FMS kinase inhibitors US Patent  US10800764 Publication Date 10/13/2020 
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CD_antigen: CD115 | CSF-1 receptor | CSF-1-R | CSF-1R | CSF1R_RAT | Csf1r | Csfmr | Fms | M-CSF-R | Proto-oncogene c-Fms
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109259.61
Organism:
Rattus norvegicus (Rat)
Description:
Q00495
Residue:
978
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFAC
  
Inhibitor
Name:
BDBM276743
Synonyms:
US10071991, Compound (P) | US10800764, Compound (P) | US11214566, Compound (P) | US9611259, Compound (P)
Type:
Small organic molecule
Emp. Form.:
C27H35N5O2
Mol. Mass.:
461.5991
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 |c:5|
Structure:
Search PDB for entries with ligand similarity: