Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM466846
Substrate
n/a
Meas. Tech.
Biological Activity Assay
IC50
<100±n/a nM
Citation
 Yao, Y; Chen, B; Chen, Y; Li, A; Xu, R; Huang, Z; Tian, D; Li, H; Yang, C; Li, J; Chen, S Indole derivative used as CRTH2 inhibitor US Patent  US10800765 Publication Date 10/13/2020 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM466846
Synonyms:
US10800765, Example 70
Type:
Small organic molecule
Emp. Form.:
C23H24FN3O4S
Mol. Mass.:
457.518
SMILES:
CN1CN(C2CC2)S(=O)(=O)c2ccc(Cc3c(C)n(CC(O)=O)c4ccc(F)cc34)cc12
Structure:
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