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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM466909
Substrate
n/a
Meas. Tech.
pCHK1 Cellular Assay
IC50
301±n/a nM
Citation
 Di Francesco, ME; Jones, P; Carroll, CL; Cross, JB; Kang, Z; Johnson, MG; Lively, S Heterocyclic inhibitors of ATR kinase US Patent  US10800774 Publication Date 10/13/2020 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM466909
Synonyms:
2-{6-[(3R)-3- Methylmorpholin-4-yl]-2- {1H-pyrrolo[2,3-b]pyridin-4- yl}pyrimidin-4-yl}-6- (propan-2-yl)-1lambda6,2,6- thiadiazinane-1,1-dione | US10800774, Example 8
Type:
Small organic molecule
Emp. Form.:
C22H29N7O3S
Mol. Mass.:
471.576
SMILES:
CC(C)N1CCCN(c2cc(nc(n2)-c2ccnc3[nH]ccc23)N2CCOC[C@H]2C)S1(=O)=O |r|
Structure:
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