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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM466915
Substrate
n/a
Meas. Tech.
pCHK1 Cellular Assay
IC50
166±n/a nM
Citation
 Di Francesco, ME; Jones, P; Carroll, CL; Cross, JB; Kang, Z; Johnson, MG; Lively, S Heterocyclic inhibitors of ATR kinase US Patent  US10800774 Publication Date 10/13/2020 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM466915
Synonyms:
(3R)-3-Methyl-4-[6-(oxan-4- yl)-2-{1H-pyrrolo[2,3-b]- pyridin-4-yl}pyrimidin-4-yl]- morpholine | US10800774, Example 14
Type:
Small organic molecule
Emp. Form.:
C21H25N5O2
Mol. Mass.:
379.4555
SMILES:
C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1CCOCC1 |r|
Structure:
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