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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM466926
Substrate
n/a
Meas. Tech.
pCHK1 Cellular Assay
IC50
139±n/a nM
Citation
 Di Francesco, ME; Jones, P; Carroll, CL; Cross, JB; Kang, Z; Johnson, MG; Lively, S Heterocyclic inhibitors of ATR kinase US Patent  US10800774 Publication Date 10/13/2020 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM466926
Synonyms:
2-Cyclopropyl-1-(4-{6-[(3R)- 3-methylmorpholin-4-yl]-2- {1H-pyrrolo[2,3-b]pyridin-4- yl}pyrimidin-4-yl}piperidin- 1-yl) ethan-1-one | US10800774, Example 25
Type:
Small organic molecule
Emp. Form.:
C26H32N6O2
Mol. Mass.:
460.5713
SMILES:
C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1CCN(CC1)C(=O)CC1CC1 |r|
Structure:
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