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Target
Beta-lactamase
Ligand
BDBM466994
Substrate
n/a
Meas. Tech.
Inhibition of Beta-Lactamase Enzymes
IC50
>100000±n/a nM
Citation
 Comita-Prevoir, J; Durand-Reville, TF; Gauthier, L; O''Donnell, J; Romero, J; Tommasi, R; Verheijen, JC; Wu, F; Wu, X; Zhang, J Beta-lactamase inhibitor compounds US Patent  US10800778 Publication Date 10/13/2020 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC
Type:
Protien
Mol. Mass.:
41561.62
Organism:
Escherichia coli
Description:
P00811
Residue:
377
Sequence:
MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWGYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVKPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSIINGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ
  
Inhibitor
Name:
BDBM466994
Synonyms:
(2S)-2-[[(2S,5R)-2- (acetamidomethyl)-3-methyl-7- oxo-1,6-diazabicyclo[3.2.1]oct-3- en-6-yl]oxy]-2-fluoro-acetic acid lithium salt | US10800778, Example 78
Type:
Small organic molecule
Emp. Form.:
C12H16FN3O5
Mol. Mass.:
301.2709
SMILES:
CC(=O)NC[C@H]1N2C[C@@H](C=C1C)N(O[C@@H](F)C(O)=O)C2=O |r,c:9|
Structure:
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