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Target
Tyrosine-protein kinase BTK
Ligand
BDBM467291
Substrate
n/a
Meas. Tech.
Cell Proliferation Assays
IC50
123±n/a nM
Citation
 Zhao, X; Zhang, W; Chen, Z; Chen, L; Wang, X; Li, Z; Tan, R; Yang, L; Tan, H; Liu, B; Ran, K; Zou, Z; Lin, M; Sun, J; Wang, W Substituted pyrrolo[2,3-d]pyridazin-4-ones and pyrazolo[3,4-d]pyridazin-4-ones as protein kinase inhibitors US Patent  US10800785 Publication Date 10/13/2020 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM467291
Synonyms:
7-amino-3-((S)-1-((E)-3-((R)-1-ethylazetidin-2- yl)acryloyl)piperidin-3-yl)-1-(4-(2-fluorophenoxy) phenyl)-1,5-dihydro-4H-pyrrolo[2,3-d]pyridazin- 4-one | US10800785, Example 110
Type:
Small organic molecule
Emp. Form.:
C31H33FN6O3
Mol. Mass.:
556.6305
SMILES:
CCN1CC[C@@H]1\C=C\C(=O)N1CCC[C@H](C1)c1cn(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12 |r|
Structure:
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