Reaction Details Report a problem with these data
Target
Uridine phosphorylase 1
Ligand
BDBM135810
Substrate
n/a
Meas. Tech.
Study with Mouse and Human Intestinal Tissue Homogenates
IC50
<100000±n/a nM
Citation
 Garland, WA; Frenzel, BD; Karg, T Methotrexate adjuvants to reduce toxicity and methods for using the same US Patent  USRE48253 Publication Date 10/13/2020 
Target
Name:
Uridine phosphorylase 1
Synonyms:
UP | UPP1 | UPP1_HUMAN | UPase 1 | UrdPase 1 | Uridine phosphorylase (UPase)
Type:
Enzyme
Mol. Mass.:
33939.54
Organism:
Homo sapiens (Human)
Description:
Q16831
Residue:
310
Sequence:
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGGSPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLHELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKTDLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVSYFIKKKLSKA
  
Inhibitor
Name:
BDBM135810
Synonyms:
US8853227, TK- 000016 | USRE48253, Designation TK-000016
Type:
Small organic molecule
Emp. Form.:
C17H18N2O5S
Mol. Mass.:
362.4
SMILES:
Cc1ccc(SCc2cn3[C@@H]4O[C@H](CO)C(O)[C@@H]4Oc3nc2=O)cc1 |r|
Structure:
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