Target
Complement factor D
Ligand
BDBM468593
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JAPhadke, ASDeshpande, MAgarwal, AChen, DGadhachanda, VRHashimoto, APais, GWang, QWang, XGreenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468593
Synonyms:
1-(2-((2S,4R)-2-(3- (4-chloro-2-((S)-1- hydroxyethyl)-1H- benzo[d]imidazol- 5-yl)-2- fluorophenyl- carbamoyl)-4- fluoropyrrolidin-1- yl)-2-oxoethyl)-1H- indazole-3- carboxamide | US10807952, Cmp No. 14
Type:
Small organic molecule
Emp. Form.:
C30H26ClF2N7O4
Mol. Mass.:
622.022
SMILES:
C[C@H](O)c1nc2c(Cl)c(ccc2[nH]1)-c1cccc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2nc(C(N)=O)c3ccccc23)c1F |r|
Structure:
Search PDB for entries with ligand similarity: