Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468659
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent US10807952 Publication Date 10/20/2020
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM468659
Synonyms:
(2S,4R)-1-(2-(3- carbamoyl-5- methoxyphenyl) acetyl)-N-(2'-chloro-2- fluorobiphenyl-3- yl)-4- fluoropyrrolidine-2- carboxamide | US10807952, Cmp No. 63
Type:
Small organic molecule
Emp. Form.:
C27H24ClF2N3O4
Mol. Mass.:
527.947
SMILES:
COc1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)cc(c1)C(N)=O |r|