Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM468688
Substrate
n/a
Meas. Tech.
TBD
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Greenlee, W Compounds for treatment of immune inflammatory disorders US Patent  US10807952 Publication Date 10/20/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM468688
Synonyms:
(2S,4R)-1-(2-(3- acetyl-1H-indazol- 1-yl)acetyl)-4- fluoro-N-(2-fluoro- 3-(2-oxo-1,2,3,4- tetrahydroquinazolin-7- yl)phenyl)pyrrolidine- 2-carboxamide | US10807952, Cmp No. 96
Type:
Small organic molecule
Emp. Form.:
C30H26F2N6O4
Mol. Mass.:
572.562
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccc3CNC(=O)Nc3c2)c2ccccc12 |r|
Structure:
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