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Target
WD repeat-containing protein 5
Ligand
BDBM468839
Substrate
n/a
Meas. Tech.
TR-FRET Binding Assay
Ki
0.130±n/a nM
Citation
 Gogliotti, RD; Stauffer, SR; Jeon, K; Salovich, JM; Macdonald, JD; Mills, JJ; Meyers, KM; Alvarado, JR; Han, C; Fesik, SW; Lee, T WDR5-MLL1 inhibitors and modulators US Patent  US10807959 Publication Date 10/20/2020 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM468839
Synonyms:
US10807959, Example 109
Type:
Small organic molecule
Emp. Form.:
C30H33F4N5O
Mol. Mass.:
555.6095
SMILES:
CCn1cc(c(n1)C(F)(F)F)-c1cc(CNC(=N)C2(C)CC2)cc(c1)C(=O)N[C@@H](C1CC1)c1ccc(F)c(C)c1 |r|
Structure:
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