Reaction Details Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM468975
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay of MetAP2
IC50
20.8±n/a nM
Citation
 Ho, KK; Quan, W; Zhou, J Pyrrolidinone compounds US Patent  US10807971 Publication Date 10/20/2020 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM468975
Synonyms:
1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)tetrahydropyran- 3-yl]triazol-4-yl]-N-[(3,5- dichloro-2-fluoro- phenyl)methyl]-3-hydroxy-2- oxo-pyrrolidine-3- carboxamide, isomer 1 hydrochloride | US10807971, Example 11
Type:
Small organic molecule
Emp. Form.:
C25H23Cl2F3N6O4
Mol. Mass.:
599.389
SMILES:
N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O |r|
Structure:
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