Target
Methionine aminopeptidase 2
Ligand
BDBM468979
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay of MetAP2
IC50
30.5±2.7 nM
Citation
 Ho, KKQuan, WZhou, J Pyrrolidinone compounds US Patent  US10807971 Publication Date 10/20/2020 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
MAP2_MOUSE | Metap2 | Methionine aminopeptidase Type 2 (MetAP2) | Mnpep | P67eif2 | Peptidase M 2
Type:
Enzyme
Mol. Mass.:
52914.64
Organism:
Mus musculus (Mouse)
Description:
O08663
Residue:
478
Sequence:
MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKKGKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDILLTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGPYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM468979
Synonyms:
1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)tetrahydropyran- 3-yl]pyrazol-3-yl]-N-[(3,5- difluorophenyl)methyl]-3- hydroxy-2-oxo-pyrrolidine-3- carboxamide, isomer 1 hydrochloride | US10807971, Example 15
Type:
Small organic molecule
Emp. Form.:
C26H25F4N5O4
Mol. Mass.:
547.5014
SMILES:
N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2)C1=O |r|
Structure:
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