Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469433
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469433
Synonyms:
US10807988, Example SC_3074 | cis-5-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-4-methyl-pyridine-2-carboxylic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C29H38N4O3
Mol. Mass.:
490.637
SMILES:
COC(=O)c1cc(C)c(cn1)N1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:13.30,16.20,(-7.73,26.2,;-6.64,25.11,;-5.15,25.51,;-4.76,27,;-4.07,24.42,;-2.58,24.82,;-1.49,23.73,;-0,24.13,;-1.89,22.24,;-3.38,21.84,;-4.46,22.93,;-.8,21.15,;.67,21.63,;1.57,20.38,;2.34,19.05,;3.88,19.05,;4.65,20.38,;3.88,21.72,;2.34,21.72,;5.42,21.72,;4.65,23.05,;6.96,21.72,;5.42,19.05,;4.65,17.72,;5.42,16.38,;6.96,16.38,;7.73,17.72,;6.96,19.05,;.67,19.14,;1.14,17.67,;.11,16.53,;-1.43,16.53,;-1.43,14.99,;.11,14.99,;-.8,19.61,;-2.04,18.71,)|
Structure:
Search PDB for entries with ligand similarity: