Target
Nociceptin receptor
Ligand
BDBM469452
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, SKoenigs, RKless, AWegert, AKonetzki, IRatcliffe, PJostock, RKoch, TLinz, KSchroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469452
Synonyms:
US10807988, Example SC_3093 | cis-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-5-methoxy-benzonitrile
Type:
Small organic molecule
Emp. Form.:
C29H36N4O2
Mol. Mass.:
472.6217
SMILES:
COc1ccc(N2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3CCC3)C2=O)c(c1)C#N |r,wU:8.24,11.14,(-7.41,-17.43,;-5.96,-16.9,;-4.79,-17.9,;-5.06,-19.41,;-3.88,-20.41,;-2.43,-19.88,;-1.26,-20.88,;.21,-20.4,;1.11,-21.65,;1.88,-22.98,;3.42,-22.98,;4.19,-21.65,;3.42,-20.31,;1.88,-20.31,;4.96,-20.31,;4.19,-18.98,;6.5,-20.31,;4.96,-22.98,;4.19,-24.32,;4.96,-25.65,;6.5,-25.65,;7.27,-24.32,;6.5,-22.98,;.21,-22.89,;.69,-24.36,;-.35,-25.5,;-1.89,-25.5,;-1.89,-27.04,;-.35,-27.04,;-1.26,-22.42,;-2.5,-23.32,;-2.16,-18.37,;-3.34,-17.38,;-.71,-17.85,;.62,-17.08,)|
Structure:
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