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Target
Mu-type opioid receptor
Ligand
BDBM469460
Substrate
n/a
Meas. Tech.
Human Mu-Opioid Peptide (hMOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM469460
Synonyms:
US10807988, Example SC_3102 | cis-1-[(1-Hydroxy-cyclobutyl)-methyl]-8-methylamino-8-phenyl-3-(2-piperazin-1- yl-pyrimidin-5-yl)-1,3-diazaspiro[4.5]decan-2-one dihydrochloride
Type:
Small organic molecule
Emp. Form.:
C28H39N7O2
Mol. Mass.:
505.655
SMILES:
CN[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)c2cnc(nc2)N2CCNCC2)CC1)c1ccccc1 |r,wU:5.10,2.1,(5.47,7.44,;6.24,6.1,;5.47,4.77,;4.7,3.43,;3.16,3.43,;2.39,4.77,;1.48,6.01,;.02,5.54,;.02,4,;-1.23,3.09,;1.48,3.52,;1.96,2.06,;.93,.91,;2.42,.51,;-.61,.91,;-.61,-.63,;.93,-.63,;-1.16,6.53,;-2.61,6.01,;-3.78,7,;-3.51,8.52,;-2.06,9.04,;-.89,8.05,;-4.69,9.51,;-4.42,11.03,;-5.59,12.02,;-7.04,11.5,;-7.31,9.98,;-6.14,8.99,;3.16,6.1,;4.7,6.1,;6.24,3.43,;5.47,2.1,;6.24,.77,;7.78,.77,;8.55,2.1,;7.78,3.43,)|
Structure:
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