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Target
Nociceptin receptor
Ligand
BDBM469764
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, R; Kless, A; Wegert, A; Konetzki, I; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807988 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469764
Synonyms:
US10807988, Example SC_3401 | cis-1-(Cyclobutyl-methyl)-8-(3-fluorophenyl)-8-methylamino-3-[2- (trifluoromethyl)-pyrimidin-5-yl]-1,3-diazaspiro[4.5]decan-2-one
Type:
Small organic molecule
Emp. Form.:
C25H29F4N5O
Mol. Mass.:
491.5243
SMILES:
CN[C@]1(CC[C@]2(CN(C(=O)N2CC2CCC2)c2cnc(nc2)C(F)(F)F)CC1)c1cccc(F)c1 |r,wU:5.10,2.1,(12.36,-8.78,;13.13,-10.11,;12.36,-11.45,;11.59,-12.78,;10.05,-12.78,;9.28,-11.45,;8.37,-10.2,;6.91,-10.68,;6.91,-12.22,;5.58,-12.99,;8.37,-12.69,;9.14,-14.03,;8.37,-15.36,;6.83,-15.36,;6.83,-16.9,;8.37,-16.9,;5.82,-9.59,;6.22,-8.1,;5.13,-7.01,;3.64,-7.41,;3.24,-8.9,;4.33,-9.99,;2.55,-6.32,;1.07,-6.72,;2.95,-4.83,;1.46,-5.23,;10.05,-10.11,;11.59,-10.11,;13.13,-12.78,;12.36,-14.11,;13.13,-15.45,;14.67,-15.45,;15.44,-14.11,;16.98,-14.11,;14.67,-12.78,)|
Structure:
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