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Target
Nociceptin receptor
Ligand
BDBM469812
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469812
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(2-methyl-pyridin-3-yl)-acetamide | US10807989, Example SC_1040
Type:
Small organic molecule
Emp. Form.:
C29H39N5O2
Mol. Mass.:
489.6523
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3cccnc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.23,(-8.6,-21.01,;-7.51,-22.1,;-6.02,-21.7,;-7.91,-23.59,;-7.91,-25.13,;-9.24,-25.9,;-10.57,-25.13,;-11.98,-24.5,;-13.01,-25.65,;-14.5,-25.25,;-15.59,-26.34,;-15.19,-27.82,;-17.07,-25.94,;-18.16,-27.03,;-19.65,-26.63,;-20.74,-27.72,;-20.34,-29.21,;-18.85,-29.6,;-17.77,-28.51,;-16.28,-28.91,;-12.24,-26.98,;-13.01,-28.31,;-10.73,-26.66,;-9.65,-27.75,;-10.04,-29.24,;-11.38,-30.01,;-10.61,-31.34,;-9.27,-30.57,;-10.57,-23.59,;-9.24,-22.82,;-6.42,-23.99,;-6.02,-25.47,;-4.53,-25.87,;-3.44,-24.78,;-3.84,-23.3,;-5.33,-22.9,)|
Structure:
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