Target
Nociceptin receptor
Ligand
BDBM469841
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.40±n/a nM
Citation
 Kuehnert, SKoenigs, RMJakob, FKless, ARatcliffe, PJostock, RKoch, TLinz, KSchroeder, WSchiene, KWegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469841
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(4-methoxy-pyrimidin-5-yl)-acetamide | US10807989, Example SC_1069
Type:
Small organic molecule
Emp. Form.:
C28H38N6O3
Mol. Mass.:
506.6397
SMILES:
COc1ncncc1NC(=O)CN1C[C@]2(CC[C@@](CC2)(N(C)C)c2ccccc2)N(CC2CCC2)C1=O |r,wU:14.31,17.21,(-21.23,16.27,;-19.9,15.5,;-19.9,13.96,;-21.23,13.19,;-21.23,11.65,;-19.9,10.88,;-18.57,11.65,;-18.57,13.19,;-17.23,13.96,;-15.9,13.19,;-15.9,11.65,;-14.56,13.96,;-13.23,13.19,;-11.77,13.67,;-10.86,12.42,;-10.09,11.09,;-8.55,11.09,;-7.78,12.42,;-8.55,13.76,;-10.09,13.76,;-6.69,13.51,;-5.2,13.11,;-7.09,15,;-6.45,11.65,;-6.45,10.11,;-5.11,9.34,;-3.78,10.11,;-3.78,11.65,;-5.11,12.42,;-11.77,11.18,;-11.37,9.69,;-12.46,8.6,;-14,8.6,;-14,7.06,;-12.46,7.06,;-13.23,11.65,;-14.56,10.88,)|
Structure:
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