Target
Nociceptin receptor
Ligand
BDBM469856
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.10±n/a nM
Citation
 Kuehnert, SKoenigs, RMJakob, FKless, ARatcliffe, PJostock, RKoch, TLinz, KSchroeder, WSchiene, KWegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469856
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-isoxazol-3-yl-acetamide | US10807989, Example SC_1084
Type:
Small organic molecule
Emp. Form.:
C26H35N5O3
Mol. Mass.:
465.5878
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)Nc3ccon3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(13.27,-7.57,;14.36,-8.66,;15.85,-8.26,;13.96,-10.15,;13.96,-11.69,;12.63,-12.46,;11.29,-11.69,;10,-10.85,;8.8,-11.82,;7.32,-11.42,;6.23,-12.51,;6.63,-14,;4.74,-12.11,;3.65,-13.2,;4.13,-14.66,;2.88,-15.57,;1.64,-14.66,;2.11,-13.2,;9.36,-13.26,;8.59,-14.59,;10.89,-13.18,;11.98,-14.26,;11.58,-15.75,;10.25,-16.52,;11.02,-17.86,;12.35,-17.09,;11.29,-10.15,;12.63,-9.38,;15.45,-10.55,;15.85,-12.03,;17.33,-12.43,;18.42,-11.34,;18.02,-9.86,;16.54,-9.46,)|
Structure:
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