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Target
Nociceptin receptor
Ligand
BDBM469863
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469863
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-[(4-methyl-pyridin-3-yl)-methyl]-acetamide | US10807989, Example SC_1091
Type:
Small organic molecule
Emp. Form.:
C30H41N5O2
Mol. Mass.:
503.6788
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cnccc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-6.65,5.28,;-5.56,4.19,;-4.07,4.59,;-5.96,2.7,;-5.96,1.16,;-7.29,.39,;-8.62,1.16,;-9.91,2,;-11.11,1.03,;-12.6,1.43,;-13.69,.34,;-13.29,-1.14,;-15.18,.74,;-16.26,-.35,;-17.75,.05,;-18.15,1.54,;-19.64,1.94,;-20.73,.85,;-20.33,-.64,;-18.84,-1.04,;-18.44,-2.53,;-10.56,-.4,;-11.33,-1.74,;-9.02,-.32,;-7.93,-1.41,;-8.33,-2.9,;-9.67,-3.67,;-8.9,-5,;-7.56,-4.23,;-8.62,2.7,;-7.29,3.47,;-4.47,2.31,;-4.07,.82,;-2.58,.42,;-1.49,1.51,;-1.89,3,;-3.38,3.39,)|
Structure:
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