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Target
Nociceptin receptor
Ligand
BDBM469869
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.60±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469869
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-[(2-methyl-pyridin-3-yl)-methyl]-acetamide | US10807989, Example SC_1097
Type:
Small organic molecule
Emp. Form.:
C30H41N5O2
Mol. Mass.:
503.6788
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCc3cccnc3C)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-7.28,29.98,;-6.19,28.89,;-4.7,29.29,;-6.59,27.4,;-6.59,25.86,;-7.92,25.09,;-9.26,25.86,;-10.55,26.7,;-11.75,25.73,;-13.23,26.13,;-14.32,25.04,;-13.92,23.55,;-15.81,25.44,;-16.9,24.35,;-18.39,24.75,;-18.78,26.24,;-20.27,26.63,;-21.36,25.55,;-20.96,24.06,;-19.47,23.66,;-19.08,22.17,;-11.19,24.29,;-11.96,22.96,;-9.66,24.37,;-8.57,23.28,;-8.97,21.8,;-10.3,21.03,;-9.53,19.69,;-8.2,20.46,;-9.26,27.4,;-7.92,28.17,;-5.1,27,;-4.7,25.52,;-3.22,25.12,;-2.13,26.21,;-2.53,27.69,;-4.01,28.09,)|
Structure:
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