Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM469883
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.30±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469883
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(1,1-dioxo-thian-4-yl)-acetamide | US10807989, Example SC_1112
Type:
Small organic molecule
Emp. Form.:
C28H42N4O4S
Mol. Mass.:
530.722
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NC3CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.24,3.2,(-4.87,7.17,;-4.47,5.68,;-2.98,5.28,;-5.56,4.59,;-6.33,3.26,;-7.87,3.26,;-8.64,4.59,;-9.54,5.84,;-11.01,5.36,;-12.34,6.13,;-13.68,5.36,;-13.68,3.82,;-15.01,6.13,;-16.34,5.36,;-17.68,6.13,;-19.01,5.36,;-19.01,3.82,;-19.41,2.33,;-20.5,4.22,;-17.68,3.05,;-16.34,3.82,;-11.01,3.82,;-12.34,3.05,;-9.54,3.35,;-9.14,1.86,;-10.23,.77,;-11.77,.77,;-11.77,-.77,;-10.23,-.77,;-7.87,5.92,;-6.33,5.92,;-4.22,3.82,;-4.22,2.28,;-2.89,1.51,;-1.56,2.28,;-1.56,3.82,;-2.89,4.59,)|
Structure:
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