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Target
Nociceptin receptor
Ligand
BDBM469922
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
0.900±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469922
Synonyms:
CIS-2-[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-N-(2-methylsulfonyl-ethyl)-acetamide | US10807989, Example SC_1152
Type:
Small organic molecule
Emp. Form.:
C26H40N4O4S
Mol. Mass.:
504.685
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)NCCS(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:3.2,6.21,(17.11,-6.79,;17.5,-8.28,;18.99,-8.68,;16.42,-9.37,;15.65,-10.7,;14.11,-10.7,;13.34,-9.37,;12.43,-8.12,;10.97,-8.6,;9.63,-7.83,;8.3,-8.6,;8.3,-10.14,;6.96,-7.83,;5.63,-8.6,;4.3,-7.83,;2.96,-8.6,;1.63,-7.83,;1.87,-9.69,;4.05,-9.69,;10.97,-10.14,;9.63,-10.91,;12.43,-10.62,;12.83,-12.1,;11.74,-13.19,;10.2,-13.19,;10.2,-14.73,;11.74,-14.73,;14.11,-8.04,;15.65,-8.04,;17.75,-10.14,;17.75,-11.68,;19.08,-12.45,;20.42,-11.68,;20.42,-10.14,;19.08,-9.37,)|
Structure:
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