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Target
Nociceptin receptor
Ligand
BDBM469982
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.20±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM469982
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[2-(4-methylsulfonyl-piperazin-1- yl)-2-oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1216
Type:
Small organic molecule
Emp. Form.:
C28H43N5O4S
Mol. Mass.:
545.737
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCN(CC3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(-6.65,15.18,;-5.88,13.85,;-4.34,13.85,;-6.65,12.52,;-7.42,11.18,;-8.96,11.18,;-9.73,12.52,;-10.64,13.76,;-12.1,13.29,;-13.19,14.38,;-14.68,13.98,;-15.08,12.49,;-15.77,15.07,;-15.37,16.55,;-16.46,17.64,;-17.95,17.24,;-18.34,15.76,;-17.26,14.67,;-19.03,18.33,;-18.64,19.82,;-20.57,18.33,;-19.43,16.84,;-12.1,11.75,;-13.44,10.98,;-10.64,11.27,;-10.24,9.78,;-11.33,8.69,;-12.87,8.69,;-12.87,7.15,;-11.33,7.15,;-8.96,13.85,;-7.42,13.85,;-5.88,11.18,;-6.65,9.85,;-5.88,8.51,;-4.34,8.51,;-3.57,9.85,;-4.34,11.18,)|
Structure:
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