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Target
Nociceptin receptor
Ligand
BDBM470058
Substrate
n/a
Meas. Tech.
Human Nociceptin/Orphanin FQ Peptide (hNOP) Receptor Binding Assay
Ki
1.000±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Wegert, A 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10807989 Publication Date 10/20/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM470058
Synonyms:
CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-(4-methylsulfonyl-piperidin-1- yl)-2-oxo-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10807989, Example SC_1366
Type:
Small organic molecule
Emp. Form.:
C28H42N4O4S
Mol. Mass.:
530.722
SMILES:
CN(C)[C@]1(CC[C@]2(CN(CC(=O)N3CCC(CC3)S(C)(=O)=O)C(=O)N2CC2CC2)CC1)c1ccccc1 |r,wU:6.25,3.2,(18.09,17.49,;18.09,15.95,;19.43,15.18,;16.76,15.18,;15.99,13.85,;14.45,13.85,;13.68,15.18,;12.77,16.43,;11.31,15.95,;9.97,16.72,;8.64,15.95,;8.64,14.41,;7.31,16.72,;7.31,18.26,;5.97,19.03,;4.64,18.26,;4.64,16.72,;5.97,15.95,;3.31,19.03,;1.97,18.26,;2.54,20.36,;4.08,20.36,;11.31,14.41,;9.97,13.64,;12.77,13.93,;13.54,12.6,;12.45,11.51,;10.97,11.11,;12.06,10.02,;14.45,16.51,;15.99,16.51,;17.53,13.85,;16.76,12.51,;17.53,11.18,;19.07,11.18,;19.84,12.51,;19.07,13.85,)|
Structure:
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