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Target
Sphingosine 1-phosphate receptor 5
Ligand
BDBM321314
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human S1P5 Receptors
EC50
5.01±n/a nM
Citation
 Stoit, A; Iwema Bakker, WI; Coolen, HK; van Dongen, MJ; Leflemme, NJ; Hobson, A Spiro-cyclic amine derivatives as S1P modulators US Patent  US10807991 Publication Date 10/20/2020 
Target
Name:
Sphingosine 1-phosphate receptor 5
Synonyms:
EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41796.42
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
398
Sequence:
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
  
Inhibitor
Name:
BDBM321314
Synonyms:
US10179791, Compound 132 | US10807991, Compound 132
Type:
Small organic molecule
Emp. Form.:
C22H21Cl3FNO4
Mol. Mass.:
488.764
SMILES:
OC(=O)CCN1CCC2(COc3c2ccc(OCc2c(Cl)cc(Cl)cc2Cl)c3F)CC1
Structure:
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