Reaction Details Report a problem with these data
Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM321330
Substrate
n/a
Meas. Tech.
In Vitro Functional Activity (Agonism) on Human S1P1 Receptors (Method A)
EC50
>31623±n/a nM
Citation
 Stoit, A; Iwema Bakker, WI; Coolen, HK; van Dongen, MJ; Leflemme, NJ; Hobson, A Spiro-cyclic amine derivatives as S1P modulators US Patent  US10807991 Publication Date 10/20/2020 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM321330
Synonyms:
US10179791, Compound 276 | US10807991, Compound 276
Type:
Small organic molecule
Emp. Form.:
C22H32FNO4
Mol. Mass.:
393.4922
SMILES:
CCCCCCCOc1ccc2c(OCC22CCN(CCC(O)=O)CC2)c1F
Structure:
Search PDB for entries with ligand similarity: