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Target
Wee1-like protein kinase
Ligand
BDBM470177
Substrate
n/a
Meas. Tech.
WEE1 IC50 Determination
IC50
33.0±n/a nM
Citation
 Chakravarty, S; Pham, SM; Kankanala, J; Agarwal, AK; Pujala, B; Soni, S; Arya, SK; Palve, D; Kumar, V Heterocyclic compounds and uses thereof US Patent  US10807994 Publication Date 10/20/2020 
Target
Name:
Wee1-like protein kinase
Synonyms:
Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN
Type:
PROTEIN
Mol. Mass.:
71599.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1445054
Residue:
646
Sequence:
MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
  
Inhibitor
Name:
BDBM470177
Synonyms:
US10807994, Compound 1.53 | US10807994, Example S-53
Type:
Small organic molecule
Emp. Form.:
C23H22Cl2N6O3
Mol. Mass.:
501.365
SMILES:
COc1cc(Nc2ncc3C(=O)N(COc3n2)c2c(Cl)cccc2Cl)ccc1N1CCNCC1
Structure:
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