Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM356558
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<10±n/a nM
Citation
 Yao, W; Zhang, C; Xu, M; Zhuo, J; He, C Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 US Patent  US10813930 Publication Date 10/27/2020 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
CD_antigen: CD333 | FGFR-3 | FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | JTK4
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Homo sapiens (Human)
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM356558
Synonyms:
N-{3-[7-(1-{1-[(3-hydroxycyclobutyl)carbonyl]piperidin-4-yl}-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]phenyl}-N′-(2,2,2-trifluoroethyl)urea | US10213427, Example 47 | US10813930, Ex. No. 47
Type:
Small organic molecule
Emp. Form.:
C28H29F3N8O3
Mol. Mass.:
582.5769
SMILES:
OC1CC(C1)C(=O)N1CCC(CC1)n1cc(cn1)-c1cnn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1 |(-12.59,3.29,;-12.2,1.8,;-12.97,.47,;-11.63,-.3,;-10.86,1.03,;-11.23,-1.79,;-12.32,-2.88,;-9.75,-2.19,;-8.66,-1.1,;-7.17,-1.5,;-6.77,-2.99,;-7.86,-4.08,;-9.35,-3.68,;-5.28,-3.39,;-4.38,-2.14,;-2.91,-2.62,;-2.91,-4.16,;-4.38,-4.63,;-1.58,-1.85,;-1.58,-.31,;-.25,.46,;1.09,-.31,;2.55,.17,;3.46,-1.08,;2.55,-2.32,;1.09,-1.85,;-.25,-2.62,;2.95,1.66,;1.86,2.75,;2.26,4.23,;3.75,4.63,;4.84,3.54,;6.33,3.94,;7.41,2.85,;7.02,1.37,;8.9,3.25,;9.99,2.16,;11.48,2.56,;11.88,4.05,;12.57,1.47,;12.97,2.96,;4.44,2.06,)|
Structure:
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