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Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM470253
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
30.3±n/a nM
Citation
 Masuda, E; Shaw, S; Taylor, V; Bhamidipati, S RIP1 inhibitory compounds and methods for making and using the same US Patent  US10815206 Publication Date 10/27/2020 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM470253
Synonyms:
US10815206, Compound I-30 | US10815206, Compound I-36 | US10815206, Compound I-62 | US10815206, Compound I-63 | US10815206, Compound I-86
Type:
Small organic molecule
Emp. Form.:
C25H24N5O4
Mol. Mass.:
458.4892
SMILES:
CN1c2cc(ccc2OC[C@H](NC(=O)c2nnc(Cc3ccccc3)n2)C1=O)C#CC(C)(C)O |r|
Structure:
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