Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM470604
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
IC50
0.053±n/a nM
Citation
Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibit Mcl-1 protein US Patent US10821115 Publication Date 11/3/2020 More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
Inhibitor
Name:
BDBM470604
Synonyms:
(1 S,3′R,6′R,7′R,8′E, 11′S,12′R)-6-CHLORO-7′-METHOXY-11′,12′-DIMETHYL-7′-(((3R)-3-METHYL-4-(1-METHYLETHYL)-1-PIPERAZINYL)METHYL)-3,4-DIHYDRO-2H, 15′H-SPIRO [NAPHTHALENE-1,22′-[20]OXA[13]THIA[1,14]DIAZATETRACYCLO[14.7.2.0-3,6˜.0˜19,24˜]PENT ACOSA[8,16,18,24]TETRAEN]-15′-ONE 13′,13′-DIOXIDE | US10821115, Example 8 | US11224601, Example 8
Type:
Small organic molecule
Emp. Form.:
C42H59ClN4O5S
Mol. Mass.:
767.46
SMILES:
CO[C@]1(CN2CCN(C(C)C)[C@H](C)C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:15|
Structure:
