Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM470614
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
IC50
0.060±n/a nM
Citation
 Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibit Mcl-1 protein US Patent  US10821115 Publication Date 11/3/2020 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Inhibitor
Name:
BDBM470614
Synonyms:
US10821115, Example 18
Type:
Small organic molecule
Emp. Form.:
C27H32BrClN2O5
Mol. Mass.:
579.91
SMILES:
COC(=O)c1ccc(OC[C@@]2(CNC[C@@H]3CC[C@H]3COC(C)=O)CCCc3cc(Cl)ccc23)c(Br)n1 |r|
Structure:
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