Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM470846
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
IC50
0.061±n/a nM
Citation
 Harrington, PEAshton, KBrown, SPKaller, MRKohn, TJLanman, BALi, KLi, YLow, JDMinatti, AEPickrell, AJStec, MMTaygerly, J Compounds that inhibit Mcl-1 protein US Patent  US10821115 Publication Date 11/3/2020 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Inhibitor
Name:
BDBM470846
Synonyms:
(1S,3''R,6''R,7''S,8''E,11''S,12''R)- 6-chloro-7''-(((9aS)-2,2- dioxidohexahydropyrazino[2,1- c][1,4]thiazin-8(1H)- yl)methyl)-7''-methoxy-11'',12''- dimethyl-3,4-dihydro-2H,15''H- spiro[naphthalene-1,22''- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15''-one 13'',13''-dioxide | US10821115, Example 231 | US10821115, Example 232 | US11224601, Example 232
Type:
Small organic molecule
Emp. Form.:
C41H55ClN4O7S2
Mol. Mass.:
815.481
SMILES:
CO[C@@]1(CN2CCN3CCS(=O)(=O)C[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:18|
Structure:
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