Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM471379
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
IC50
0.056±n/a nM
Citation
 Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibit Mcl-1 protein US Patent  US10821115 Publication Date 11/3/2020 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
  
Inhibitor
Name:
BDBM471379
Synonyms:
US10821115, Example 100394 | US10821115, Example 100395 | US11224601, Example 100395
Type:
Small organic molecule
Emp. Form.:
C35H41ClN2O6S
Mol. Mass.:
653.228
SMILES:
C[C@H]1C\C=C\[C@@](O)(C#CCO)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)NS(=O)(=O)[C@@H]1C |r,t:3|
Structure:
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