Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM471528
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
IC50
0.057±n/a nM
Citation
Harrington, PE; Ashton, K; Brown, SP; Kaller, MR; Kohn, TJ; Lanman, BA; Li, K; Li, Y; Low, JD; Minatti, AE; Pickrell, AJ; Stec, MM; Taygerly, J Compounds that inhibit Mcl-1 protein US Patent US10821115 Publication Date 11/3/2020
More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Homo sapiens (Human)
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
Inhibitor
Name:
BDBM471528
Synonyms:
US10821115, Example 100545 | US10821115, Example 100561 | US10821115, Example 100562 | US11224601, Example 100562
Type:
Small organic molecule
Emp. Form.:
C39H48ClN3O8S
Mol. Mass.:
754.332
SMILES:
CO[C@@]1(CC(=O)N[C@H]2CCOC2=O)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:14|