Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM471633
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
7.60±n/a nM
Citation
 Ali, A; Huang, X; Lim, Y; Kuang, R; Wu, H; Anand, R; Yu, Y; Metzger, E; Man-Chu Lo, M; Ting, PC; Stamford, AW; Tempest, P Substituted aminoquinazoline compounds as A2A antagonist US Patent  US10822338 Publication Date 11/3/2020 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM471633
Synonyms:
(R)-7-methoxy-2-(1- (4,4,4- trifluorobutyl)piperidin- 3-yl)- [1,2,4]triazolo[1,5- c]quinazolin-5-amine | US10822338, Example 16
Type:
Small organic molecule
Emp. Form.:
C19H23F3N6O
Mol. Mass.:
408.4207
SMILES:
COc1cccc2c3nc(nn3c(N)nc12)[C@@H]1CCCN(CCCC(F)(F)F)C1 |r|
Structure:
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