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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM412893
Substrate
n/a
Meas. Tech.
Patch-Clamp Assay
IC50
<500±n/a nM
Citation
 Tasler, S; Krimmelbein, I; Kraus, J; Zaja, M KV1.3 inhibitors and their medical application US Patent  US10822345 Publication Date 11/3/2020 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM412893
Synonyms:
US10399991, Example 10 | US10822345, Ex 10
Type:
Small organic molecule
Emp. Form.:
C22H20O4
Mol. Mass.:
348.3918
SMILES:
CCOc1ccccc1-c1c(C)c(=O)oc2c(C)c3occ(C)c3cc12 |(5.85,1.54,;4.52,2.31,;3.19,1.54,;1.85,2.31,;1.85,3.85,;.52,4.62,;-.82,3.85,;-.82,2.31,;.52,1.54,;.52,,;1.85,-.77,;3.19,,;1.85,-2.31,;3.19,-3.08,;.52,-3.08,;-.82,-2.31,;-2.15,-3.08,;-2.15,-4.62,;-3.48,-2.31,;-4.95,-2.79,;-5.85,-1.54,;-4.95,-.29,;-5.42,1.17,;-3.48,-.77,;-2.15,,;-.82,-.77,)|
Structure:
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