Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM412911
Substrate
n/a
Meas. Tech.
Patch-Clamp Assay
IC50
1000±n/a nM
Citation
 Tasler, SKrimmelbein, IKraus, JZaja, M KV1.3 inhibitors and their medical application US Patent  US10822345 Publication Date 11/3/2020 
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM412911
Synonyms:
US10399991, Example 28 | US10822345, Ex 28
Type:
Small organic molecule
Emp. Form.:
C20H16BrNO2
Mol. Mass.:
382.251
SMILES:
Cc1coc2c(C)c3[nH]c(=O)c(Br)c(-c4ccccc4C)c3cc12 |(-4.09,1.17,;-3.61,-.29,;-4.52,-1.54,;-3.61,-2.79,;-2.15,-2.31,;-.82,-3.08,;-.82,-4.62,;.52,-2.31,;1.85,-3.08,;3.19,-2.31,;4.52,-3.08,;3.19,-.77,;4.52,,;1.85,,;1.85,1.54,;.52,2.31,;.52,3.85,;1.85,4.62,;3.19,3.85,;3.19,2.31,;4.52,1.54,;.52,-.77,;-.82,,;-2.15,-.77,)|
Structure:
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