Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354272
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent US10822352 Publication Date 11/3/2020
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM354272
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(2-(methylamino) pyrimidin-5-yl)-1H- indol-1-yl)acetyl)- N-(2'-chloro-2- fluorobiphenyl-3-yl)- 4-fluoropyrrolidine-2- carboxamide | US10287301, Compound 188 | US10822352, Comp No. 188 | US9796741, cmp No. 188
Type:
Small organic molecule
Emp. Form.:
C34H29ClF2N6O3
Mol. Mass.:
643.082
SMILES:
CNc1ncc(cn1)-c1ccc2n(CC(=O)N3C[C@H](F)C[C@H]3C(=O)Nc3cccc(c3F)-c3ccccc3Cl)cc(C(C)=O)c2c1 |r|