Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM386263
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM386263
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5-(2-(2,2,2- trifluoroethylamino) pyrimidin-5-yl)- 1H-indol-1- yl)acetyl)-N-(2'- chloro-2- fluorobiphenyl-3- yl)-4- fluoropyrrolidine-2- carboxamide | US10287301, Compound 193 | US10822352, Comp No. 193
Type:
Small organic molecule
Emp. Form.:
C35H28ClF5N6O3
Mol. Mass.:
711.08
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(cc12)-c1cnc(NCC(F)(F)F)nc1 |r|
Structure:
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