Target
Complement factor D
Ligand
BDBM386333
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Wiles, JAPhadke, ASDeshpande, MAgarwal, AChen, DGadhachanda, VRHashimoto, APais, GWang, QWang, X Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders US Patent  US10822352 Publication Date 11/3/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM386333
Synonyms:
(2S,4R)-1-(2-(3- acetyl-5-(3-cyano-2- methylpyrazolo[1,5- a]pyrimidin-6-yl)- 1H-indazol-1- yl)acetyl)-N-(6- bromopyridin-2- yl)-4- fluoropyrrolidine-2- carboxamide | US10287301, Compound 262 | US10822352, Comp No. 262
Type:
Small organic molecule
Emp. Form.:
C29H23BrFN9O3
Mol. Mass.:
644.454
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(Br)n2)c2ccc(cc12)-c1cnc2c(C#N)c(C)nn2c1 |r|
Structure:
Search PDB for entries with ligand similarity: