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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM377182
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors US Patent  US10828290 Publication Date 11/10/2020 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM377182
Synonyms:
3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 32 | US10517858, Example 32 | US10828290, Example 32 | US11229631, Example 32
Type:
Small organic molecule
Emp. Form.:
C25H26F3N7O
Mol. Mass.:
497.5154
SMILES:
N[C@H]1CCCN(C1)c1c(NC(=O)c2nc(c(F)cc2N)-c2c(F)cccc2F)cnc2NCCCc12 |r,wU:1.0,(-5.33,2.7,;-4,1.93,;-2.67,2.7,;-1.33,1.93,;-1.33,.39,;-2.67,-.38,;-4,.39,;-2.67,-1.92,;-1.33,-2.69,;,-1.92,;1.33,-2.69,;1.33,-4.23,;2.67,-1.92,;2.67,-.38,;4,.39,;5.33,-.38,;6.67,.39,;5.33,-1.92,;4,-2.7,;4,-4.24,;4,1.93,;2.67,2.69,;1.33,1.93,;2.67,4.23,;4,5,;5.33,4.23,;5.33,2.69,;6.67,1.93,;-1.33,-4.23,;-2.67,-5,;-4,-4.23,;-5.33,-5,;-6.67,-4.23,;-6.67,-2.69,;-5.33,-1.92,;-4,-2.69,)|
Structure:
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