Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM424958
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors US Patent  US10828290 Publication Date 11/10/2020 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM424958
Synonyms:
N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10517858, Example 37 | US10828290, Example 37 | US11229631, Example 37
Type:
Small organic molecule
Emp. Form.:
C26H26F3N5O3
Mol. Mass.:
513.5115
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:5.5,1.0,wD:7.8,(-.15,3.28,;-1.48,2.51,;-1.48,.97,;-2.82,.2,;-4.15,.97,;-4.15,2.51,;-5.48,3.28,;-2.82,3.28,;-2.82,4.82,;-2.82,-1.34,;-4.15,-2.11,;-5.61,-1.63,;-6.52,-2.88,;-5.61,-4.13,;-6.09,-5.59,;-4.15,-3.65,;-2.82,-4.42,;-1.48,-3.65,;-1.48,-2.11,;-.15,-1.34,;1.18,-2.11,;1.18,-3.65,;2.52,-1.34,;3.85,-2.11,;5.19,-1.34,;5.19,.2,;6.52,.97,;3.85,.97,;2.52,.2,;3.85,2.51,;5.19,3.28,;6.52,2.51,;5.19,4.82,;3.85,5.59,;2.52,4.82,;2.52,3.28,;1.18,2.51,)|
Structure:
Search PDB for entries with ligand similarity: