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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM377223
Substrate
n/a
Meas. Tech.
Pim Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors US Patent  US10828290 Publication Date 11/10/2020 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM377223
Synonyms:
US10265307, Example 59-2 | US10517858, Example 59 (Diastereoisomer 2) | US10828290, Example 59 (Diastereoisomer 2) | US11229631, Example 59 Diastereoisomer 2
Type:
Small organic molecule
Emp. Form.:
C26H26F3N5O3S
Mol. Mass.:
545.577
SMILES:
CS(=O)c1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@H](O)CCc2c1N1CCC[C@H](N)C1 |r,wU:35.39,wD:25.27,(5.19,6.76,;3.85,5.99,;2.52,6.76,;3.85,4.45,;2.52,3.68,;2.52,2.14,;1.18,1.37,;3.85,1.37,;5.19,2.14,;6.52,1.37,;5.19,3.68,;3.85,-.17,;2.52,-.94,;2.52,-2.48,;3.85,-3.25,;5.19,-2.48,;5.19,-.94,;6.52,-.17,;1.18,-3.25,;1.18,-4.79,;-.15,-2.48,;-1.48,-3.25,;-1.48,-4.79,;-2.82,-5.56,;-4.15,-4.79,;-5.61,-5.27,;-6.01,-6.76,;-6.52,-4.02,;-5.61,-2.78,;-4.15,-3.25,;-2.82,-2.48,;-2.82,-.94,;-1.48,-.17,;-1.48,1.37,;-2.82,2.14,;-4.15,1.37,;-5.48,2.14,;-4.15,-.17,)|
Structure:
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