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Target
Mu-type opioid receptor
Ligand
BDBM472012
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
9.00±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472012
Synonyms:
CIS-8-Dimethylamino-1-(1-hydroxy-cyclobutyl)-methyl]-3-[(4-methoxyphenyl)- methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2051
Type:
Small organic molecule
Emp. Form.:
C29H39N3O3
Mol. Mass.:
477.6383
SMILES:
COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCC3)C2=O)cc1 |r,wU:9.25,12.15,(-19.29,-13.54,;-17.95,-14.31,;-16.62,-13.54,;-16.62,-12,;-15.29,-11.23,;-13.95,-12,;-12.62,-11.23,;-11.28,-12,;-9.82,-11.53,;-8.91,-12.77,;-8.14,-14.11,;-6.6,-14.11,;-5.83,-12.77,;-6.6,-11.44,;-8.14,-11.44,;-5.06,-11.44,;-5.83,-10.11,;-3.52,-11.44,;-5.06,-14.11,;-5.83,-15.44,;-5.06,-16.78,;-3.52,-16.78,;-2.75,-15.44,;-3.52,-14.11,;-9.82,-14.02,;-9.42,-15.51,;-10.51,-16.6,;-10.11,-18.08,;-11.28,-15.26,;-12.61,-16.03,;-11.84,-17.37,;-11.28,-13.54,;-12.62,-14.31,;-13.95,-13.54,;-15.29,-14.31,)|
Structure:
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