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Target
Mu-type opioid receptor
Ligand
BDBM472061
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
9.10±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472061
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclopentyl)-methyl]-3-[(4-methoxyphenyl)- methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2075
Type:
Small organic molecule
Emp. Form.:
C30H41N3O3
Mol. Mass.:
491.6648
SMILES:
COc1ccc(CN2C[C@]3(CC[C@@](CC3)(N(C)C)c3ccccc3)N(CC3(O)CCCC3)C2=O)cc1 |r,wU:9.25,12.15,(-19.29,-24.68,;-17.95,-25.45,;-16.62,-24.68,;-16.62,-23.14,;-15.29,-22.37,;-13.95,-23.14,;-12.62,-22.37,;-11.28,-23.14,;-9.82,-22.66,;-8.91,-23.91,;-8.14,-25.24,;-6.6,-25.24,;-5.83,-23.91,;-6.6,-22.58,;-8.14,-22.58,;-5.06,-22.58,;-5.83,-21.24,;-3.52,-22.58,;-5.06,-25.24,;-5.83,-26.58,;-5.06,-27.91,;-3.52,-27.91,;-2.75,-26.58,;-3.52,-25.24,;-9.82,-25.16,;-9.42,-26.64,;-10.51,-27.73,;-9.18,-28.5,;-12,-27.33,;-12.84,-28.63,;-11.87,-29.82,;-10.43,-29.27,;-11.28,-24.68,;-12.62,-25.45,;-13.95,-24.68,;-15.29,-25.45,)|
Structure:
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